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When stratified by administration route, the mean percentage changes were: Intramuscular (IM): 307% Oral: 285% Sublingual: 199% IM administration showed the highest average B12 increase, although oral and sublingual routes also yielded substantial improvements, supporting their use as effective and less invasive alternatives

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While GLP-1 agonists primarily affect the pancreas and gut to regulate insulin secretion and gastric emptying, cagrilintide acts on the brain to suppress appetite and food intake