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Hepatic lipid was extracted, as previously described (Folch et al

For eye-area products, 2% is more appropriate because the skin around the eyes is thinner and more reactive

These effects of AMPK are, in part, due to the phosphorylation and activation of the cyclic nucleotide phosphodiesterase, PDE4B

At 265 lb, exposure ran 25% to 30% lower. On that class-based model, 1 mg in a 155 lb person can approximate the exposure produced by 1.5 mg in the 240 lb trial cohort