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In contrast, the bioavailability of SC MTX is dose-dependent and linear, displaying no plateau (Schiff et al

Gudowska M, Gruszewska E, Panasiuk A, Cylwik B, Flisiak R, widerska M, et al

Corcoran RB, Falchook GS, Infante JR, Hamid O, Messersmith WA, Daud A, Kwak EL, Ryan DP, Kurzrock R, Atreya CE, Luan J, Sun P, Schaeffer M, Motwani M, Bleam MR, Moy CH, Patel K, Orford KW, Kopetz S , Venook AP

Murphy MP, Bayir H, Belousov V, Chang CJ, Davies KJA, Davies MJ et al (2022) Guidelines for measuring reactive oxygen species and oxidative damage in cells and in vivo

Some protocols use up to 1,000 mg per day under medical supervision