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Additionally, estrogens seem to be necessary for axonal growth and synaptic plasticity (von Schassen et al., 2006), improving the performance on different memory and cognition tests (Wallace et al., 2006)

In fact, much of the high reactivity of ROS is due to their generation of such molecular chain reactions, effectively amplifying their effects many fold

Some data suggests that the area accessible to G-proteins on the receptor is insufficient for transduction of the receptor signal to the relatively large trimeric G-protein complex (Park et al., 2004)

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doi: 10.1038/s41388-021-01930-2 99 WorthingtonH