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These properties make ARA-290 a primary reagent for laboratories investigating neuropathic pathology, chronic inflammation, and the non-hematopoietic functions of the EPO pathway

2012 (PMID 22129598), which introduced the HGF-dimerization framing, was retracted in 2025 (retraction notice PMID 40312092)

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For this purpose, we adopted two approaches: (1) a proteomic approach using FLAG-tagged macrocycles and (2) live-cell imaging using fluorescently labelled macrocycles