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Oral B12 supplementation is more accessible and cost-effective but relies on gastric intrinsic factor for absorption, rendering it unsuitable for individuals with gastric disorders or malabsorption syndromes

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Some complications develop over time, leading to long-term pain, mobility issues, and functional impairment

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Subcutaneous B12 administration, although promising in select cases such as congenital cobalamin disorders, lacks comprehensive comparative studies against IM and oral routes