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Populations at elevated risk are people on blood thinners, immune suppression, and those with severe kidney or liver disease

The physical agitation can break the delicate amino acid bonds, damaging the molecule and rendering it ineffective

Thus, berberine combined with atorvastatin may be an efficient therapeutic method to treat atherosclerosis

10.1073/pnas.1401876111 PNAS 14 EsteyT.KangJ.SchwendemanS