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During our previous characterization of molecular pathways leading to wheat resistance to Hessian fly using microarrays, we have found that the transcript levels of a large number of genes encoding various enzymes involved in glutathione metabolism are strongly affected in resistant plants after Hessian fly attack 21,27 , indicating that glutathione may play an important role in wheat defense against Hessian fly attack

Without these data, even a positive skin outcome would be difficult to attribute to a specific mechanism, and a safe cumulative-dose ceiling could not be defined

Metabolism 60 , 17811789 (2011)

Macromolecular bioscience