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Zonal pattern of distribution (centrilobular, periportal, midzonal) may be present

10.1016/s0014-2999(00)00207-7 Summary Keywords acetaminophen, N -acylphenolamine, analgesia, brain, spinal dorsal horn Citation Ohashi N and Kohno T (2020) Analgesic Effect of Acetaminophen: A Review of Known and Novel Mechanisms of Action

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Under the therapeutic concentrations, approximately 60%90% of APAP is metabolized in the liver by glucuronidation and sulfation, with a small part (approximately 5%15%) being metabolized by the cytochrome P450 pathway (CYP450) (Kalsi et al., 2011