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Rubbing can push medication out of the subcutaneous layer and increase bruising

Improved glucose uptake means better blood sugar regulation and less excess glucose available to be converted into fat

High-dose or prolonged pyridoxine supplementation can also lead to alterations in other nutrient levels, for example, extended use of large doses has been associated with reduced serum folate concentrations in some reports, which suggests a need to monitor nutritional balance during long-term therapy

Benoist 2014, PMID 25187433) were retracted in April 2025 (retraction notices PMID 40312092 and PMID 40312093) following a Washington State University investigation that found the lead author altered images across her dissertation and multiple co-authored papers

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