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These results were consistent with the findings of elevated urinary levels of the marker of lipid peroxidation, isoprostane F 2 -VI, the marker of platelet activation, 2,3-dinor-thromboxane B 2 , and the marker of endothelial activation, 6-keto-prostaglandin F 1 in 26 children diagnosed with ASD [117]

doi: 10.3390/molecules25235508

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The increased oxidative stress seems to be the second hit in the progression from NAFL to NASH: the increase in ROS and consequently in lipid peroxidation has been associated to hepatocellular damage, inflammation, and eventual fibrosis due to the activation of hepatic stellate cells