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Maternal High-Fat Diet Impairs Placental Fatty Acid -Oxidation and Metabolic Homeostasis in the Offspring

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12, 13, 14 Together, the pathological features of T2Dnotably elevated serum concentrations of inflammatory cytokines, glucose, insulin and free insulin-like growth factor-1 (IGF-1)provide a pro-tumorigenic environment that may account for the increased risk of diabetic and obese patients for the development of cancer at various sites 11 as well as the worse prognosis of patients with cancer that display one or more of these abnormalities

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