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Genes encoding several glycolytic enzymes, such as phosphoglycerate kinase 1, enolase, aldolase A, LDHA, and phosphofructokinase, have been proposed to be direct targets of HIF1 [134,135,136,137,138]

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Because of its role in cellular energy, NAD+ IV therapy has been explored for benefits such as improved cognitive function, reduced fatigue, and potential anti-aging effects