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6.2 Hyperglycemia-induced oxidative stress pathways Glycated hemoglobin (HbA1c), which averages blood sugar levels over the previous two to 3 months within total red blood cell hemoglobin, is a measure of the degree of glucoses natural binding to hemoglobin (glycation)

Nicotinamide analogs such as 6-methylaminonicotinamide form one class of NNMT inhibitors that work by mimicking the natural substrate, NAM, and competing for the enzymes active site 197

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