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Exerts potent anti-inflammatory effects in the gut and CNS by modulating nitric oxide pathways and reducing pro-inflammatory cytokines, closely resembling the protective actions of the native gastric peptide in response to mucosal injury

These actions prevent mitochondrial calcium overload and apoptosis (136)

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Therapeutic hypothermia after cardiac arrest cerebral perfusion and metabolism during upper and lower threshold normocapnia

Pre-treatment of mito-TEMPO to 5-FU challenged animals noticeably decreased the expression of 8-OHdG as compared to 5-FU group which indicated the protective action of mito-TEMPO against 5-FU mediated DNA damage (Fig