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Dihexa, a synthetic mimetic of Angiotensin IV, is a peptide of particular interest in neuroscience, studied for its potent neurogenic and synaptogenic capabilities
Although these peptides are still under investigation and not approved for human use, research models suggest several potential biological roles
NSAIDs have also been shown to cause oxidative stress via a mitochondria-independent mechanism in vascular tissue (Li 2008)
Notably, excessive ROS can further exacerbate calcium homeostasis disorders by damaging the sarcoplasmic reticulum Ca-ATPase and mitochondrial calcium uniporter, forming a malignant cascade of excessive ROS-calcium imbalance-energy crisis [136]