Nature 477 , 482485 (2011)
To determine the assay window for the FP assay, the TIN2-FAM probe was prepared as a 16-M stock in aqueous buffer and titrated from 0 to 400 nM against either a constant concentration of TRF1 TRFH (0.5 M in FP buffer) or FP buffer alone (25 mM HEPES-NaOH pH 7.5, 100 mM NaCl, 1 mM TCEP, 0.05% w/v CHAPS)
It causes no irritation, sensitization, phototoxicity, or comedogenicity in standard dermatological testing (RIPT, phototoxicity panel, comedogenicity assay)
DallAcqua WF, Woods RM, Ward ES, Palaszynski SR, Patel NK, Brewah YA, et al
Additionally, Sermorelin's effects decline when pituitary capacity is exhausted or inhibitory signals (somatostatin) are active, providing intrinsic safety compared to pharmacological GH administration