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This decreases production of intrinsic factor and secretion of hydrochloric acid in the stomach, two things that affect your body's absorption of B12

A thicker needle is necessary for IM injections to penetrate the muscle tissue effectively

Neelakantan et al., Biochemical Pharmacology, 2018, gave diet-induced obese mice the compound and reported it significantly reduced body weight and white adipose mass, decreased adipocyte size, with food intake unchanged (PMID 29155147) [3]

What is missing There is no published human pharmacokinetic study of subcutaneous AOD-9604, no published human topical or intranasal exposure data, no Phase 3 efficacy trial, no long-term safety data beyond 24 weeks, and no published human cartilage or joint outcome data