While it can be effective, ongoing administration without breaks might reduce its effectiveness over time 1
The multifaceted mechanism of action of 5FU involves direct incorporation of its metabolites into DNA (FdUTP) and RNA (FUTP), as well as inhibition of thymidylate synthase (TS) via FdUMP 4,5 , making it more difficult to identify rational combination partners that would enhance clinical responses without eliciting adverse systemic toxicity
The difference is that peptides are smaller, more targeted, and act as messenger molecules that communicate with certain cells/tissues and tell them what to do
[DOI] [PMC free article] [PubMed] [Google Scholar] 74.Wise L.A., Radin R.G., Palmer J.R., Kumanyika S.K., Boggs D.A., Rosenberg L
Raithel M, Hagel AF, Zopf Y, et al