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Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents

In a mouse model of breast cancer (PyMT), the depletion of intratumoral macrophages (colony stimulating factor 1 (CSF-1) null mutant mice) or the conditional knock-out of their secreted VEGF led to a delay of the angiogenic switch of the tumor vasculature (5961)

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Once obtained, H 2 O 2 can be degraded in mitochondria via the GSH redox system, employing glutathione peroxidases (Gpxs) and GRs, but also through peroxiredoxins (Prxs), a family of thiol-specific peroxidases

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