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In this study, phosphotoxic protein inhibited melanin synthesis by downregulating the expression of MITF, TRP-1, TRP-2, and tyrosinase in B16F10 cells and reducing cAMP levels (Jung et al., 2012)

GIP (Glucose-Dependent Insulinotropic Polypeptide) An incretin hormone that enhances insulin secretion, supports fat metabolism, and appears to reduce GLP-1-related nausea when activated simultaneously with GLP-1 receptors

In this study, the authors reported that the severity of IBS was positively correlated with low CH 4 exhaled, low microbial richness, absence of Methanobacteriales and enrichment with Bacteroides enterotypes