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Drugs like enclomiphene or HCG can help restart natural production

Oxidative modification experiments have demonstrated that the epoxide moiety disrupts the planar rigidity and electron density distribution of the steroid nucleus, thereby affecting its binding affinity to viral transcriptional regulatory elements ( The chemical integrity of distinct regions within the steroid nucleus is pivotal for sustaining biological potency

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There were no significant changes in occludin, zona occludens-1, and zona occludens-2 expression when assessed by western blotting, qPCR, or immunofluorescence (data not shown)

Journal of Ethnopharmacology, 137 (3), 1143-1148