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In SH-SY5Y neurons, ESC activated Nrf2, increased glutathione (GSH) levels, and protected against oxidative stress and amyloid-beta (A) oligomer-induced apoptosis

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Ethics declarations Ethics approval and consent to participate Given that this manuscript is a review article and does not involve any direct research on human or animal subjects, ethical approval and consent to participate are not applicable

10.1007/s11064-008-9841-3 Neurochem

Hydroxocobalamin has a long safety record, no meaningful overdose risk because excess is excreted in urine, and a very low rate of allergic reactions