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AOD-9604 is a synthetic peptide fragment derived from the C-terminal region of human growth hormone that specifically targets fat metabolism without systemic growth hormone effects

Disordered regions mediate the interaction of p53 and MRE11

The practical advantages of topical: easy to apply, local delivery, lower systemic exposure, and you don't need a needle

Also in this setting, the potency of FOXO4-DRI was more pronounced when applied in consecutive rounds Not only did FOXO4-DRI selectively target the senescent cells, but it was also effective agains the induced chemo-toxicity observed in the form of liver toxicity and body weight loss