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Moreover, VK2 suppresses the MAPK/NF-B axis, resulting in decreased production of MMP3 and MMP13, while enhancing the synthesis of type II collagen and proteoglycans, so collectively mitigating ECM breakdown [114]

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Negatively charged targets are mainly represented by phospholipids, such as PS, which are secluded in the inner side of the plasmatic membrane in normal cells, but increasing the content of PS and accordingly increasing the cancer cell's negative charge allows for the specificity of ACPs (176,177,178)

We often see a lack of vitamin B12 in many vegans or vegetarians as b12 is usually found in animal products