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Concurrent iron-deficiency anemia and folic acid deficiency may result in a blunted or impeded response to cyanocobalamin therapy.1

Incorrect reconstitution can result in particle formation, incorrect concentration, or pH changes that all affect injection comfort

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It is best to limit caffeine intake for a few hours after a B12 shot to ensure optimal absorption

After initiation and dose increases, patients should be observed carefully for signs and symptoms of pancreatitis (including persistent severe abdominal pain, sometimes radiating to the back and which may or may not be accompanied by vomiting)