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Before elective orthopaedic surgery, it is recommended to discontinue GLP-1 medications as they can delay gastric emptying and increase aspiration risk during anesthesia

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Therefore, DON treatment can not only reduce the self-renewal potential and metastatic ability of pancreatic ductal adenocarcinoma (PDAC) tumor cells but also lead to extensive remodeling of the tumor extracellular matrix (ECM), promoting the infiltration and activation of CD8 + T cells (Sharma et al., 2020)

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In severe cases, a deficiency can even lead to a swollen and inflamed tongue and mouth, known as glossitis