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alternative routes have unknown safety implications Efficacy : The dose-response relationship established in trials assumes subcutaneous delivery Tolerability : Gastrointestinal adverse effects (nausea, vomiting, diarrhea) are dose-dependent and may be affected by altered absorption Patients with lower body mass index or those injecting in areas with less subcutaneous fat may be at higher risk of inadvertent intramuscular injection if proper technique is not followed

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Dihexa was engineered for oral bioavailability through modifications that resist proteolytic degradation and facilitate blood-brain barrier penetration via passive diffusion

In the same hippocampal region, and after cerebral ischemia, HGF also decreases the activity of the NADPH oxidase and consequent ROS generation in glia-like cells (Niimura et al., 2006c)

They serve different purposes.