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Contributing factors may include B12 or folate deficiency (since methionine generation requires these nutrients), or excessive SAMe utilization in polyamine synthesis as part of a maladaptive chronic inflammatory response to tau pathology (10, 11)

High expression of both desaturases correlates with reduced relapse-free survival (RFS, hazard ratio [HR] = 1.4, log-rank P = 0.04, n = 534, Fig

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decreased utilisation of amino acids for protein synthesis and cell proliferation