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First, preclinical findings are primarily based on in vitro and xenograft models, which do not fully replicate the complexity of human AML, including interactions within the tumor microenvironment

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We initially built an exploratory sPLS model with the number of components set at ten

In general, in vitro exposure of neural cells to aluminum has been shown to result in pronounced alterations in mitochondrial structure and function, leading to marked increases in ROS, reduction of mitochondrial enzyme activity, and cell death [45]

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