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Thus, anti-CD20 therapies, such as rituximab have earned a prominent role in treatment of cancers, including B cell lymphomas, Hodgkin lymphoma, Burkitt lymphoma, and B cell lymphoblastic leukemias (159)

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However, the therapeutic utility of doxorubicin is undermined by its dose-dependent cardiotoxicity, possibly arising as a result of futile redox cycling, with NADH dehydrogenase within the mitochondria proposed as the most likely site of anthracycline reduction 9,10

Clinical Cancer Research