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Ammonia-induced mitochondrial dysfunction and energy metabolism disturbances in isolated brain and liver mitochondria, and the effect of taurine administration: relevance to hepatic encephalopathy treatment

Lysyl oxidase, the copper-dependent enzyme that catalyzes the oxidative deamination of lysine residues in collagen and elastin (a step required for the cross-linking that gives mature collagen and elastin their mechanical properties), requires copper as a cofactor

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Along with the microglial foot processes and the basement membrane of the glia, astrocyte end-feet form the perivascular space border, which represents the last barrier to the entry of leukocytes and other infiltrating cells into the brain tissue (Man et al., 2007)