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This nuclear presence of FOXO4 seems to be involved in maintaining the viability of senescent cells by possibly modulating downstream senescence-associated pathways, detailed by changes in p53, Ser15-phospho-p53, and p21 protein levels

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Ercan H, Birben E, Dizdar EA, Keskin O, Karaaslan C, et al: Oxidative stress and genetic and epidemiologic determinants of oxidant injury in childhood asthma