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Whats the science say

The damage caused by ROS arises from the partial reduction of oxygen

What they did: Isolated human chondrocytes (from osteoarthritis patients and healthy donors) were exposed to AOD-9604 at doses 1 to 1000 nM

Particularly the pyruvate dehydrogenase kinase isoenzyme-4 gene encodes PDK that converts pyruvate, CoA and oxidized nicotinamide adenine dinucleotide (NAD+) into acetyl-CoA, the reduced form of nicotinamide adenine dinucleotide (NADH) and carbon dioxide