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The use of Vitamin B12 injections for weight loss has become one of such methods that have gained the attention of people

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Increased levels of DNA methylation of the Trim13 gene promoter in DKD result in lower production of Trim13, decreased proteasomal degradation and ubiquitination of CHOP, and increased collagen synthesis[45]

In those cases symptoms indicating B12 deficiency may arise, and injections are necessary

(PubMed) Carter P, Gray LJ, Troughton J, Khunti K, Davies MJ