#2 This is from the 2008 500 handbook
Biondi-Zoccai G, Sciarretta S, Bullen C, Nocella C, Violi F, Loffredo L, Pignatelli P, Perri L, Peruzzi M, Marullo AGM, De Falco E, Chimenti I, Cammisotto V, Valenti V, Coluzzi F, Cavarretta E, Carrizzo A, Prati F, Carnevale R, Frati G (2019) Acute effects of heat-not-burn, electronic vaping, and conventional tobacco combustion cigarettes: the Sapienza University of RomeVascular assessment of proatherosclerotic effects of smoking (SUR-VAPES) 2 randomized trial
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On each occasion, the researchers measured volunteers heart rate and blood pressure and collected a blood sample before they used the e-cigarettes, then 15 minutes after use and again 60 minutes after use
Tobacco companies have worked hard to come up with products that replicate smoking without causing all the harms of inhaling combusted tobacco, and they think theyve accomplished that with modern heated tobacco products (HTPs), which are also sometimes called heat-not-burn (HNB) tobacco products