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Mice null for Fbxo40 have increased levels of IRS1 and demonstrate enhanced body and muscle size during the growth phase associated with elevated IGF1 levels. Moreover, IGF-1 LR3 also helps with muscle repair via improving the proliferative capacity of muscle satellite cells (MSCs)

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This is supported by clinical data across multiple study populations

Front Plant Sci 13:868874 Song YH, Ito S, Imaizumi T (2013) Flowering time regulation: photoperiod- and temperature-sensing in leaves

However, TQs hydrophobic nature and poor bioavailability have hindered its usefulness as a therapeutic agent