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It has been proposed that ATXN3 contributes to facilitate the proteasomal degradation of ubiquitylated proteins by editing polyubiquitin chains of a subset of substrates prior to digestion [69] and to protect others from degradation [70,71,72]

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ICIs have been associated with low ORRs in patients with METex14 -altered NSCLC (1736% with ICI monotherapy 139 ), and responses do not seem to correlate with PD-L1 expression or TMB 138

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