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It is primarily studied for its ability to upregulate telomerase activity, the enzyme responsible for rebuilding telomeres (the protective caps at the ends of chromosomes)

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From a clinical perspective, the lack of large-scale human trials means it cannot yet be considered an established therapy

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Western blot analysis of thoracic aorta proteins showed that the classic aging markers P21 and P16 were significantly downregulated following FOXO4-DRI treatment, whereas the expression levels of the cell proliferation marker Ki-67 and Lamin B, a key protein involved in nuclear structural stability, were markedly upregulated (Figure 1A)