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Second, data on smoking status was addressed only once, at baseline, which would not capture change of these health behaviors during the follow-up

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This discussion includes that the long-term safety of NVPs is unknown, that there is a lack of high quality evidence of the health benefit from a tobacco harm reduction approach using NVPs, and that people who use NVPs have an approximately double the risk of relapse to combustible tobacco smoking compared with non-NVP users

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