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IR arises from deficient insulin action in target tissues, leading to hyperinsulinemia and metabolic disorders such as hyperglycaemia, dyslipidaemia, and endothelial dysfunction [3, 4]

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Zhang H, Wu M, Zhu X, Li C, Li X, Jin W, Zhang D, Chen H, Liu C, Ding Y, Niu J, Liu J

By the time most people reach their fifties, their average daily GH secretion is a fraction of what it was at twenty-five and with it, the downstream signalling that supports muscle maintenance, fat metabolism, and sleep architecture all shift accordingly

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