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Surgical Intervention Reserved for large goitres causing compressive symptoms or cosmetic concerns Subtotal thyroidectomy may be considered in select cases Prognosis ~5% of subclinical hypothyroid patients progress to overt disease per year

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Biochem J 468:7385 Lescot M, Dhais P, Thijs G et al (2002) PlantCARE, a database of plant cis-acting regulatory elements and a portal to tools for in silico analysis of promoter sequences

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