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While AOD9604 has not achieved the commercial success initially envisioned, it has contributed valuable insights into the dissociable functions of different regions of the growth hormone molecule and has validated the concept that targeted metabolic effects can be achieved without unwanted growth hormone receptor activation

Research has demonstrated that DSIP modulates the hypothalamic-pituitary-adrenal (HPA) axis, reducing basal corticotropin (ACTH) levels and blocking stress-induced ACTH release

This is now FDA APPROVED with registration number printed on the left side of the bottle

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In some embodiments, the otic formulation or composition comprises about 0.9% by weight of the therapeutic agent, or pharmaceutically acceptable prodrug or salt thereof