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Long-term acid suppression, particularly with proton pump inhibitor (PPI) therapy, has been associated with potential micronutrient deficiencies, including vitamin B12 and magnesium deficiency, while altered gastric pH may also influence the dissolution and absorption of selected orally administered drugs (78, 84)

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Human Clinical Trials A 12-week facial cream study enrolling 71 women with mild to advanced photoaging documented multiple improvements: increased skin density and thickness, reduced laxity, improved clarity, and reduced fine lines with decreased wrinkle depth

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