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doi: 10.1128/mcb.21.4.1249-1259.2001 40 McMillanR

Preferential expression of IGF-1Ec (MGF) transcript in cancerous tissues of human prostate: evidence for a novel and autonomous growth factor activity of MGF E peptide in human prostate cancer cells

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When CYP1A2 (Phase I) oxidizes an aromatic amine to its N-hydroxy derivative, and then O-acetyltransferase activity (catalyzed by the same NAT enzymes) transfers an acetyl group to the oxygen, it creates a highly reactive N-acetoxyarylamine that binds DNA

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