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The base form (crack or freebase) is typically smoked Cocaine is rapidly metabolized in the liver and blood into two primary, inactive metabolites: benzoylecgonine and ecgonine methyl ester (which are targets for drug analysis)

Additionally, oxidative stress and mitochondrial dysfunction induced by MPs are believed to impair GABAergic neuron function, leading to decreased GABA levels in the cerebral cortex of rats exposed to PS-MPs (Oyovwi et al., 2024), with implications for epilepsy and ASD ( Moreover, exposure to MPs can impair neuronal synaptic function, which is essential for the normal operation of neural networks

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Sci Rep 2015;5:9392

Medication Interactions Research has not identified any interactions with specific medications