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Traditional treatments for AD, such as cholinesterase inhibitors and NMDA receptor antagonists, offer only modest symptomatic relief, while L-DOPA for PD primarily addresses motor symptoms, with limited efficacy against non-motor dysfunctions and progression

The rationale for studying them together is straightforward: if two compounds affect different but converging pathways involved in tissue repair, their combined application in experimental models may reveal interactions that cannot be observed when studying either compound in isolation

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Szymanowicz O, Druzdz A, Slowikowski B, Pawlak S, Potocka E, Goutor U, Konieczny M, Ciaston M, Lewandowska A, Jagodzinski PP, Kozubski W, Dorszewska J (2024) A Review of the CACNA Gene Family: Its Role in Neurological Disorders, Diseases, 12 Crosbie EJ, Kitson SJ, McAlpine JN, Mukhopadhyay A, Powell ME, Singh N (2022) Endometrial cancer