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Sikiric group: extensive rat-model evidence of gastric and intestinal cytoprotection

As DNA methylation appears to be an integral component of the pathogenesis of endometriosis, the identification of DNA methylation biomarkers would likely help better understand its causes and aggravating factors as well as potentially facilitate its diagnosis and support the development of new therapeutic approaches

Of note, the TGF/SMAD3 signaling pathway is involved in endometrial fibrosis and is thought to play an important role in adenomyosis pathobiology [74, 75]

Gradual loading prevents re-injury and improves tissue tolerance