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Defective podocyte insulin signalling through p85-XBP1 promotes ATF6-dependent maladaptive ER-stress response in diabetic nephropathy

Below, we break down the details from notable pieces of research, including the outcomes of a few completed clinical (human) trials

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McCracken JT, Anagnostou E, Arango C, Dawson G, Farchione T, Mantua V, McPartland J, Murphy D, Pandina G, Veenstra-VanderWeele J (2021) Drug development for autism spectrum disorder (ASD): progress, challenges, and future directions

The improvement at 5 mg/kg was comparable to younger (6-month) controls, suggesting near-full reversal of age-related spatial memory decline