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This severe glutamine deprivation leads to dramatic histone hypermethylation due to decreased -KG levels subsequent to decreased activity of Jumonji domain-containing histone demethylases and results in cancer cell dedifferentiation and resistance to BRAF inhibitors 103

Titusville, NJ: Janssen Pharmaceuticals May SM, Motosue MS, Park MA (2017) Dapsone is often tolerated in HIV-infected patients with history of sulfonamide antibiotic intolerance

The nephrotoxic mechanisms of IS have been characterized primarily through in vitro and animal models, with limited validation in human DKD

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